Sodium zirconium cyclosilicate Side Effects
Applies to sodium zirconium cyclosilicate: oral powder for suspension.
Serious side effects
Along with its needed effects, sodium zirconium cyclosilicate may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking sodium zirconium cyclosilicate:
More common
- Swelling
Less common
- Decreased urine
- dry mouth
- increased thirst
- irregular heartbeat
- loss of appetite
- mood changes
- muscle pain or cramps
- nausea
- numbness or tingling in the hands, feet, or lips
- seizures
- unusual tiredness or weakness
- vomiting
For Healthcare Professionals
Applies to sodium zirconium cyclosilicate: oral powder for reconstitution.
General
The most commonly reported adverse reactions reported during clinical trials included edema and hypokalemia.[Ref]
Cardiovascular
Very common (10% or more): Edema (up to 16.1%)
During clinical trials, edema was reported in 4.4% of patients receiving 5 g/day, 5.9% of patients receiving 10 g/day and 16.1% of patients receiving 15 g/day for up to 28 days (placebo 2.4%). In longer-term trials, 8% to 11% of patients receiving doses less than 15 g/day reported edema, generalized edema and peripheral edema.
Metabolic
Common (1% to 10%): Hypokalemia
Frequency not reported: Increase in sodium bicarbonate concentrations
In clinical trials, 4.1% of patients developed hypokalemia which resolved with dose reduction or discontinuation.
Small, dose-dependent increases in sodium bicarbonate occurred with once daily dosing (1.1 mmol/L at 5 g/day; 2.3 mmol/L at 10 g/day; 2.6 mmol/L at 15 g/day; 0.6 mmol/L in placebo). The clinical significance of this is unknown.
Frequently asked questions
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References
1. (2018) "Product Information. Lokelma (sodium zirconium cyclosilicate)." Astra-Zeneca Pharmaceuticals
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.