Orgovyx Side Effects
Generic name: relugolix
Medically reviewed by Drugs.com. Last updated on Nov 6, 2023.
Note: This document contains side effect information about relugolix. Some dosage forms listed on this page may not apply to the brand name Orgovyx.
Applies to relugolix: oral tablet.
Serious side effects of Orgovyx
Along with its needed effects, relugolix (the active ingredient contained in Orgovyx) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking relugolix:
Less common
- Chest pain or discomfort
- confusion
- difficulty in speaking
- double vision
- headache
- inability to move the arms, legs, or facial muscles
- inability to speak
- nausea
- pain or discomfort in the arms, jaw, back, or neck
- slow speech
- sweating
- vomiting
Rare
- Bleeding gums
- cloudy urine
- coughing up blood
- decreased frequency or amount of urine
- difficult, burning, or painful urination
- difficulty in swallowing
- dizziness
- fainting
- frequent urge to urinate
- increased menstrual flow or vaginal bleeding
- increased thirst
- loss of appetite
- lower back or side pain
- nosebleeds
- paralysis
- prolonged bleeding from cuts
- red or black, tarry stools
- red or dark brown urine
- slow, fast, pounding, or irregular heartbeat
- swelling of the face, fingers, or lower legs
- trouble breathing
- unusual tiredness or weakness
- weight gain
Incidence not known
- Large, hive-like swelling on face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
Other side effects of Orgovyx
Some side effects of relugolix may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
- Bone pain
- constipation
- diarrhea
- difficulty in moving
- feeling of warmth
- fever
- lack or loss of strength
- muscle aches, cramps, pain, or stiffness
- neck pain
- pain in the joints
- redness of the face, neck, arms and occasionally, upper chest
- stomach cramps or tenderness
- swollen joints
- watery or bloody diarrhea
Less common
- Decreased interest in sexual intercourse
- discouragement
- feeling sad or empty
- inability to have or keep an erection
- irritability
- loss in sexual ability, desire, drive, or performance
- loss of interest or pleasure
- swelling of the breasts or breast soreness
- trouble concentrating
- trouble sleeping
For Healthcare Professionals
Applies to relugolix: oral tablet.
Hematologic
Very common (10% or more): Decreased hemoglobin (28%)
Uncommon (0.1% to 1%): hemorrhage (0.3%)[Ref]
Musculoskeletal
Very common (10% or more): Musculoskeletal pain (30%)
Uncommon (0.1% to 1%): Fracture (0.3%)[Ref]
Metabolic
Very common (10% or more): Increased glucose (44%), increased triglycerides (35%)
Common (1% to 10%): Increased weight[Ref]
Psychiatric
Common (1% to 10%): Insomnia, depression, decreased libido[Ref]
Genitourinary
Uncommon (0.1% to 1%): Urinary tract infection (0.5%)[Ref]
Hepatic
Very common (10% or more): Increased alanine aminotransferase (27%), increased aspartate aminotransferase (18%)[Ref]
Oncologic
Uncommon (0.1% to 1%): Metastatic lung cancer (0.3%)[Ref]
Respiratory
Uncommon (0.1% to 1%): Pneumonia (0.3%)[Ref]
General
Very common (10% or more): Fatigue (26%)[Ref]
Renal
Uncommon (0.1% to 1%): Acute kidney injury up to 0.6%), urinary tract infection (0.5%)[Ref]
Cardiovascular
Uncommon (0.1% to 1%): Myocardial infarction (up to 0.8%), arrhythmia (0.6%), atrioventricular block (0.3%), cardiac failure (0.3%)
Frequency not reported: Fatal and non-fatal myocardial infarction, stroke[Ref]
Dermatologic
Common (1% to 10%): Hyperhidrosis[Ref]
Endocrine
Very common (10% or more): Hot flash (54%)
Common (1% to 10%): Gynecomastia[Ref]
Gastrointestinal
Very common (10% or more): Constipation (12%), diarrhea (12%)
Uncommon (0.1% to 1%): Abdominal pain (0.3%)[Ref]
More about Orgovyx (relugolix)
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- During pregnancy
- FDA approval history
- Drug class: gonadotropin-releasing hormone antagonists
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References
1. (2021) "Product Information. Orgovyx (relugolix)." Myovant Sciences, Inc.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.