Milrinone Pregnancy and Breastfeeding Warnings
Brand names: Primacor, Primacor I.V.
Medically reviewed by Drugs.com. Last updated on Apr 3, 2024.
Milrinone Pregnancy Warnings
Milrinone has been assigned to pregnancy category C by the FDA. Animal studies failed to reveal evidence of teratogenicity at doses approximately 2.5 times the recommended human dosage. Studies have revealed increased resorption rates. There are no adequate or well-controlled studies during human pregnancy. Milrinone should only be given during pregnancy when benefit outweighs risk.
Placental transfer of milrinone was noted (baboon) when loading and continuous intravenous doses resulting in plasma concentrations considered therapeutic in human were administered. The maternal to fetal baboon serum ratio was approximately 4:1 during 3 hours of infusion.
Milrinone Breastfeeding Warnings
There are no data on the excretion of milrinone into human milk.
See also
References for pregnancy information
- (2001) "Product Information. Primacor (milrinone)." Sanofi Winthrop Pharmaceuticals
- Atkinson BD, Fishburne JI, Hales KA, Levy GH, Rayburn WF (1996) "Placental transfer of milrinone in the nonhuman primate (baboon)." Am J Obstet Gynecol, 174, p. 895-6
References for breastfeeding information
- (2001) "Product Information. Primacor (milrinone)." Sanofi Winthrop Pharmaceuticals
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
