Preoperative GLP-1 Agonist Use Does Not Increase Aspiration
By Elana Gotkine HealthDay Reporter
TUESDAY, April 9, 2024 -- Preoperative glucagon-like peptide-1 (GLP-1) agonist use does not increase the risk for aspiration or subsequent pneumonia in patients undergoing various surgical procedures, according to a study presented at the 49th Annual Regional Anesthesiology and Acute Pain Medicine Meeting, held from March 21 to 23 in San Diego.
Jashvant Poeran, M.D., Ph.D., from the Icahn School of Medicine at Mount Sinai in New York City, and colleagues examined the impact of GLP-1 agonists on aspiration and subsequent pneumonia risk in patients undergoing surgical procedures in a retrospective cohort study. Data were included for 186,975 lower-extremity joint replacements; 174,277 hysterectomies; 116,234 appendectomies; and 219,110 cholecystectomies.
Preoperative use of GLP-1 agonists varied from 0.6 to 2.0 percent. The researchers found that the aspiration risk was 0.20 percent overall and pneumonia risk was 0.68 percent. Preoperative GLP-1 use was not significantly associated with the odds of aspiration or pneumonia in multivariable models. In a propensity score analysis, the results were similar.
"In this observational national dataset, preoperative GLP-1 use appears not to be associated with odds of perioperative aspiration or pneumonia," the authors write. "We believe that these data add to the current sparse evidence base. Given the very recent increases in their use, continued monitoring will be prudent."
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.
© 2024 HealthDay. All rights reserved.
Posted April 2024
Read this next
BMI Cutoff of 30 for Obesity May Be Too High for Middle-Aged, Older Adults
FRIDAY, May 31, 2024 -- The optimal body mass index (BMI) cutoff point appears to be 27 kg/m2 for detecting obesity in middle-aged and older adults, according to a study presented...
Emergency Inguinal Hernia Surgery Rates Increased With Lower Country Income
FRIDAY, May 31, 2024 -- For patients undergoing inguinal hernia surgery, emergency surgery rates increase from high- to low-income countries, according to a study published online...
Semaglutide Cuts Risk for Kidney Outcomes, Death in CKD With T2DM
FRIDAY, May 31, 2024 -- For patients with type 2 diabetes and chronic kidney disease, semaglutide reduces the risk for clinically important kidney outcomes and death from...
More news resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.