Preop Stereotactic Radiosurgery May Aid Outcomes With Resected Brain Metastases
Medically reviewed by Drugs.com.
By Lori Solomon HealthDay Reporter
MONDAY, July 10, 2023 -- Preoperative stereotactic radiosurgery (SRS) may be effective for patients with resected brain metastases, according to a study published online June 8 in JAMA Oncology.
Roshan S. Prabhu, M.D., from Atrium Health in Charlotte, North Carolina, and colleagues assessed outcomes and prognostic factors after preoperative SRS for patients with resected brain metastases. The analysis included 404 patients with resected brain metastases from solid cancers with a median dose to 15 Gy in one fraction or 24 Gy in three fractions delivered at a median of two days before resection.
The researchers found that the two-year cavity local recurrence rate was 13.7 percent. Cavity local recurrence risk was associated with systemic disease status, extent of resection, SRS fractionation, type of surgery (piecemeal versus en bloc), and primary tumor type. The two-year meningeal disease rate was 5.8 percent, with risk associated with the extent of resection, primary tumor type, and posterior fossa location. For adverse radiation effects, the two-year rate for any grade was 7.4 percent. Median overall survival was 17.2 months, which was most strongly predicted by systemic disease status, extent of resection, and primary tumor type.
"In this cohort study, the rates of cavity local recurrence, adverse radiation effects, and meningeal disease after preoperative SRS were found to be notably low," the authors write.
Abstract/Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.
© 2024 HealthDay. All rights reserved.
Posted July 2023
Read this next
Recommendations Issued for Palliative RT for Symptomatic Bone Mets
THURSDAY, May 30, 2024 -- In a clinical practice guideline issued by the American Society for Radiation Oncology and published online May 22 in Practical Radiation Oncology...
Living Outside of Comprehensive Cancer Center Catchment Area Tied to Later-Stage Diagnosis
TUESDAY, May 28, 2024 -- Disadvantaged populations and those living outside of a comprehensive cancer center's main catchment area have higher odds of receiving a diagnosis of...
Disparities Seen in Cancer Treatment Delivery at Minority-Serving Hospitals
TUESDAY, May 28, 2024 -- There are systemic disparities in definitive cancer treatment delivery at minority-serving hospitals (MSHs) versus non-MSHs, according to a study...
More news resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.