Overall Survival Benefit Up for Pyrotinib + Capecitabine in HER2-Positive Breast Cancer
By Elana Gotkine HealthDay Reporter
THURSDAY, Nov. 16, 2023 -- For patients with human epidermal growth factor receptor 2 (HER2)-positive metastatic breast cancer, pyrotinib plus capecitabine offers an overall survival benefit, according to a study presented at the Advanced Breast Cancer Seventh International Consensus Conference, held from Nov. 9 to 11 in Lisbon, Portugal.
Binghe Xu, M.D., from the Chinese Academy of Medical Sciences and Peking Union University in Shanghai, and colleagues presented an updated analysis of overall survival from the PHOEBE trial after an additional two years of follow-up. Individuals had HER2-positive metastatic breast cancer and had previously received trastuzumab and taxanes, with up to two prior lines of chemotherapy for metastatic disease. Patients were randomly assigned to receive oral pyrotinib 400 mg or lapatinib 1,250 mg once daily combined with oral capecitabine (134 and 132 patients, respectively).
The researchers found that as of data cutoff (March 15, 2023), 53.7 and 60.6 percent of patients in the pyrotinib and lapatinib groups, respectively, had died. The median overall survival was longer in the pyrotinib group than the lapatinib group (39.4 versus 28.6 months). The 36-month overall survival rate was 55.8 and 43.4 percent, respectively. In most protocol-prespecified subgroups, including patients without prior trastuzumab resistance, those with prior trastuzumab resistance, and patients without previous chemotherapy in the metastatic setting, the overall survival benefits of pyrotinib plus capecitabine over lapatinib plus capecitabine were observed.
"Pyrotinib plus capecitabine consistently shows a benefit to patients with HER2-positive metastatic disease in terms of progression-free and overall survival, irrespective of prior treatments," coauthor Xichun Hu, M.D., Ph.D., from the Fudan University Cancer Hospital in Shanghai, said in a statement.
Two of the authors disclosed employment to Jiangsu Hengrui Pharmaceuticals, which is developing pyrotinib and funded the study.
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.
© 2024 HealthDay. All rights reserved.
Posted November 2023
Read this next
Pandemic Had Temporary Negative Effect on Breast Cancer Screening
THURSDAY, May 30, 2024 -- The COVID-19 pandemic had a transient negative effect on breast cancer screening overall and a prolonged negative effect on follow-up screening...
Patient Characteristics Linked to Performance of AI Algorithm for DBT
THURSDAY, May 30, 2024 -- For analyzing negative screening digital breast tomosynthesis (DBT) examinations, patient characteristics influence the case and risk scores of an...
Chemo + Breast Cancer Combo Accelerates Functional Decline in Seniors
WEDNESDAY, May 29, 2024 -- The combination of breast cancer and chemotherapy contributes to accelerated functional decline in older women with early-stage breast cancer, according...
More news resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.