Hormone Therapy May Up Odds of GERD in Postmenopausal Women
Medically reviewed by Drugs.com.
By Elana Gotkine HealthDay Reporter
WEDNESDAY, July 5, 2023 -- Hormone therapy (HT) use is associated with increased risk of gastroesophageal reflux disease (GERD) among postmenopausal women, according to a review published online June 27 in Menopause.
Wafa A. Aldhaleei, M.B.B.Ch., M.P.H., from the Bloomberg School of Public Health at Johns Hopkins University in Baltimore, and colleagues conducted systematic review and meta-analysis to examine the association between ever or current menopause HT use and GERD. A DerSimonian and Laird random-effects model was used to pool studies published between 2008 and Aug. 31, 2022.
The researchers observed a significant direct association between estrogen use and GERD in the pooled analysis of five studies (adjusted odds ratio, 1.41), and between progestogen use and GERD in the pooled analysis of two studies (adjusted odds ratio, 1.39). There was also an association seen for use of combined HT with GERD (adjusted odds ratio, 1.16). Overall, the odds of GERD were increased in association with HT use (adjusted odds ratio, 1.29). Significant, high heterogeneity was seen as a result of the large number of pooled participants, differences in study design, geography, patient characteristics, and outcome assessment.
"Although additional research is needed, this study highlights the potential for the development of GERD symptoms with HT use," Stephanie Faubion, M.D., medical director of the North American Menopause Society, said in a statement. "A review of risk factors for GERD and implementation of lifestyle strategies for prevention, such as smoking cessation, maintaining a healthy weight, and not lying down after a heavy meal, may be helpful to avoid GERD symptoms in menopausal women considering HT use."
Abstract/Full Text (subscription or payment may be required)
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.
© 2024 HealthDay. All rights reserved.
Posted July 2023
Read this next
More Physical Activity Tied to Higher Odds of Hot Flashes
FRIDAY, May 31, 2024 -- Increases in physical activity increase the odds of menopause-related hot flashes, according to a study published online May 28 in Menopause. Sarah...
ASCO: Conjugated Equine Estrogen May Increase Risk for Ovarian Cancer
TUESDAY, May 28, 2024 -- Conjugated equine estrogen (CEE) taken alone for menopause may increase the risk for developing and dying from ovarian cancer, according to a study...
Fezolinetant Safe, Effective for Moderate-to-Severe Menopause Hot Flashes
MONDAY, May 20, 2024 -- Fezolinetant is safe and effective for moderate-to-severe vasomotor symptoms (VMS), according to a study presented at the annual European Congress of...
More news resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.