Genetic Evidence Supports Causal Effect for Diastolic BP on Benign Prostatic Hyperplasia
Medically reviewed by Drugs.com.
By Elana Gotkine HealthDay Reporter
THURSDAY, Aug. 3, 2023 -- There is genetic evidence supporting a causal effect of diastolic blood pressure (DBP) on benign prostatic hyperplasia (BPH), according to a study published online July 16 in The Prostate.
Kaikai Lv, M.D., from The Chinese People's Liberation Army General Hospital in Beijing, and colleagues conducted a two-sample Mendelian randomization (MR) study to examine the causality of metabolic syndrome (MetS) and its components on BPH using summary-level data from genome-wide association studies. Data were included for 26,358 BPH cases and 110,070 controls.
The researchers observed significant positive associations for genetically predicted waist circumference and DBP with BPH risk. No causal effect was seen for MetS, systolic blood pressure, triglycerides, high-density lipoprotein, or fasting blood glucose on BPH. The risk effect of DBP on BPH persisted after conditioning with waist circumference in the multivariable MR analysis, but no significant association for waist circumference was observed.
"Our MR study provides genetic evidence supporting the causal effect of DBP on BPH. However, the role of increased waist circumference in the risk of developing BPH requires further validation," the authors write. "Our results suggest that the management of DBP may prevent BPH development."
Abstract/Full Text (subscription or payment may be required)
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.
© 2024 HealthDay. All rights reserved.
Posted August 2023
Read this next
HTN, Albuminuria Risks No Worse for Kidney Donors Versus Nondonors
THURSDAY, May 30, 2024 -- Living kidney donors and nondonors have similar risks for hypertension and albuminuria, according to a study published online May 23 in the Journal of...
Antihypertensives Linked to Eczematous Dermatitis in Seniors
FRIDAY, May 24, 2024 -- Antihypertensive drugs are associated with an increased risk for eczematous dermatitis in older adults, and the effect sizes are largest for diuretics and...
Social Determinants of Health Explain Disparities in Treatment-Resistant Hypertension
TUESDAY, May 21, 2024 -- Part of the association between race and incident apparent treatmentāresistant hypertension (aTRH) risk is mediated by social determinants of health, a...
More news resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.