Early Antiplatelet Therapy With Mechanical Thrombectomy Shows Benefits
Medically reviewed by Drugs.com.
By Lori Solomon HealthDay Reporter
TUESDAY, Aug. 15, 2023 -- Early use of antiplatelet treatment after mechanical thrombectomy (MT) for acute ischemic stroke is associated with better functional outcomes without safety concerns, according to a study presented at the annual meeting of the Society of NeuroInterventional Surgery, held from July 31 to Aug 4 in San Diego.
Hepzibha Alexander, M.D., from Ascension Providence Hospital in Southfield, Michigan, and colleagues evaluated the safety and functional outcomes of antiplatelet use within 24 hours following MT. Analysis included prospective data for 190 consecutive patients who underwent MT for acute ischemic stroke (2016 to 2020).
The researchers found significant differences between the early and late groups for sex (61.1 percent versus 38.3 percent male), preoperative tissue plasminogen activator (24.2 versus 75.8 percent), angioplasty (23.2 versus 2.1 percent) and/or stent placement (20.0 versus 2.1 percent) and thrombectomy site (83.1 versus 97.9 percent anterior and 16.8 versus 2.1 percent posterior circulation). There was no significant difference seen between the groups for hemorrhagic transformation (symptomatic and asymptomatic) or inpatient mortality. At discharge, 30 days, and 90 days in the early group, modified Rankin scale score was significantly lower. In the early antiplatelet group, functional independence was significantly higher at discharge and at 30 days. Early antiplatelet use was independently associated with significantly higher odds of achieving functional independence at discharge (odds ratio, 3.07) and 30 days (odds ratio, 5.78). There was no independent association noted between early antiplatelet and increased odds of hemorrhagic transformation.
"Continuously working to improve patient outcomes is one of our top priorities," Alexander said in a statement. "Finding a new way to safely use this already-essential medication is an exciting step forward in helping patients thrive after stroke."
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.
© 2024 HealthDay. All rights reserved.
Posted August 2023
Read this next
Delay in Hospital Arrival After Stroke Linked to Social Vulnerability
THURSDAY, May 30, 2024 -- Areas with a high incidence of delay in hospital arrival after ischemic stroke are characterized by increased social vulnerability, according to a study...
Infarct Size Does Not Affect Treatment Effect of Early Versus Late DOAC
TUESDAY, May 28, 2024 -- For individuals with minor, moderate, or major stroke, the treatment effect of early versus late direct oral anticoagulant (DOAC) initiation does not...
Extreme Temperatures Linked to Increased Risk for Stroke Death
FRIDAY, May 24, 2024 -- Extreme cold and hot temperatures are associated with an increased risk for death from ischemic and hemorrhagic strokes, according to a study published...
More news resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.