Fosnetupitant and palonosetron (injection)

Generic name: fosnetupitant and palonosetron (injection) [ FOS-net-UE-pi-tant-and-PAL-oh-NOE-se-tron ]
Brand names: Akynzeo Injection, Akynzeo for Injection
Dosage forms: intravenous powder for injection (235 mg-0.25 mg), intravenous solution (235 mg-0.25 mg)
Drug class: Miscellaneous antiemetics

Medically reviewed by Drugs.com on May 20, 2024. Written by Cerner Multum.

What is fosnetupitant and palonosetron?

Fosnetupitant and palonosetron is used with other medications to prevent nausea and vomiting that may happen during and after chemotherapy in adults.

Fosnetupitant and palonosetron is not used to treat nausea and vomiting that you already have.

Fosnetupitant and palonosetron may also be used for purposes not listed in this medication guide.

Fosnetupitant and palonosetron side effects

Get emergency medical help if you have signs of an allergic reaction: hives, difficult breathing, swelling of your face, lips, tongue, or throat.

Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea.

Common side effects of fosnetupitant and palonosetron may include:

• headache;

• feeling weak or tired;

• skin redness; or

• upset stomach, constipation.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Related/similar drugs

ondansetron, lorazepam, dexamethasone, Zofran, Ativan, metoclopramide

Warnings

Use only as directed. Tell your doctor if you use other medicines or have other medical conditions or allergies.

Before taking this medicine

Tell your doctor if you have ever had:

• an allergic reaction to a similar medicine for nausea or vomiting, such as dolasetron, ondansetron, palonosetron, or granisetron; or

• severe liver or kidney disease.

Tell your doctor if you also use stimulant medicine, opioid medicine, herbal products, or medicine for depression, mental illness, Parkinson's disease, migraine headaches, serious infections, or prevention of nausea and vomiting. An interaction with fosnetupitant and palonosetron could cause a serious condition called serotonin syndrome.

Fosnetupitant and palonosetron may harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

Ask a doctor if it is safe to breastfeed while using fosnetupitant and palonosetron.

How is fosnetupitant and palonosetron given?

Fosnetupitant and palonosetron is usually given before the start of chemotherapy treatment.

Fosnetupitant and palonosetron is given as an infusion into a vein. A healthcare provider will give you this injection.

You may be given other medications to further help prevent nausea and vomiting. Keep taking these medicines for as long as your doctor has prescribed.

You may need blood tests after receiving fosnetupitant and palonosetron if you also take a blood thinner called warfarin.

Fosnetupitant and palonosetron dosing information

Usual Adult Dose for Nausea/Vomiting -- Chemotherapy Induced:

Fosnetupitant 235 mg-palonosetron 0.25 mg via IV infusion over 30 minutes ONCE, starting 30 minutes before chemotherapy on Day 1

ADDITIONAL MEDICATIONS:
Highly Emetogenic Cancer Chemotherapy, Including Cisplatin-Based Chemotherapy:
-Day 1: Dexamethasone 12 mg orally 30 minutes prior to chemotherapy
-Days 2 to 4: Dexamethasone 8 mg orally once a day

Use: In combination with dexamethasone for the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of highly emetogenic cancer chemotherapy

What happens if I miss a dose?

In a medical setting you are not likely to miss a dose.

What happens if I overdose?

In a medical setting an overdose would be treated quickly.

What should I avoid while receiving fosnetupitant and palonosetron?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What other drugs will affect fosnetupitant and palonosetron?

Sometimes it is not safe to use certain medicines at the same time. Some drugs can affect your blood levels of other drugs you use, which may increase side effects or make the medicines less effective.

Many drugs can affect fosnetupitant and palonosetron. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any medicine you start or stop using.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

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