What type of drug is Vitrakvi (larotrectinib)?
Medically reviewed by Drugs.com. Last updated on Nov 22, 2023.
Vitrakvi is an inhibitor of the tropomyosin receptor kinases, TRKA, TRKB, and TRKC. Vitrakvi is used to treat adults and children with solid tumors.
In November 2018 the U.S. Food and Drug Administration (FDA) approved Vitrakvi (larotrectinib), an oral treatment for adults and children with solid tumors that have a neurotrophic receptor tyrosine kinase (NTRK) gene fusion. Vitrakvi is the first TRK inhibitor for cancers that express this mutation.
- NTRK genes may be fused to other genes, leading to a TRK fusion protein that results in solid tumors across various sites.
- NTRK fusions are rare cancers but arise in many places in the body, and include soft tissue sarcoma, salivary gland cancer, infantile fibrosarcoma, thyroid cancer and lung cancer.
- Vitrakvi is also the second approval for cancers based on a common gene mutation rather than site of origin; Keytruda (pembrolizumab) was the first.
Read next
Related medical questions
- How aggressive is non-small cell lung cancer?
- Does smoking cause non-small cell lung cancer?
- What type of prostate cancer is Erleada used to treat?
- What type of lung cancer is Vizimpro used to treat?
- What type of cancer is Tecentriq used to treat?
- What type of cancer is Daurismo (glasdegib) used to treat?
- Oxycodone vs Hydrocodone - How do they compare?
- Does omeprazole cause cancer?
- Why is Xanax so addictive?
- How do you increase platelet count during chemotherapy?
- What are monoclonal antibodies?
- Vicodin vs Percocet: What's the difference?
- How do I know if immunotherapy is working?
- Why give Taxol (Paxel) before carboplatin?
- What are anti-VEGF drugs (VEGF inhibitors)?
- What is Quercetin and what are its health benefits?
- My stool has changed color. What does it mean?
- How do I know if Aldara is working for skin cancer?
- How does Ibrance kill cancer?
- Does Xolair cause cancer?
- Does Skyrizi cause cancer?
- Can Tymlos cause bone cancer?
- Is food coloring bad for you?
- How do Herceptin (trastuzumab) and Perjeta (pertuzumab) work together?
- What is a chemotherapy regimen?
- How much does Tecartus cost?
- How does chemotherapy affect the cell cycle?
- How does carboplatin stop cancer?
- How is immunotherapy administered?
- What type of drug is Lenvima? Is it a chemo drug?
Drug information
Related support groups
- Vitrakvi (1 questions, 3 members)
- Larotrectinib (1 questions, 3 members)
- Cancer (173 questions, 637 members)
- Solid Tumors (4 questions, 7 members)