Vitamin K (Phytonadione) Injection Shortage

• • Pfizer had vitamin K injection on market reserve due to increased demand. The increased demand is thought to be due to increased use of synthetic inhaled cannabinoids laced with anticoagulants.
  • Oral vitamin K is not affected by this shortage.

• • Vitamin K injection, Amphastar, 2 mg/mL, 0.5 mL SAF-T-JET prefilled syringe, 10 count, NDC 76329-1240-01
  • Vitamin K injection, Pfizer, 10 mg/mL, 1 mL ampule, 25 count, NDC 00409-9158-01
  • Vitamin K injection, Pfizer, 2 mg/mL, 0.5 mL ampule, 25 count, NDC 00409-9157-01

Estimated Resupply Dates

• • Pfizer has vitamin K injection in 1 mg/mL 0.5 mL ampules and 10 mg/mL 1 mL ampules available.

Safety

• • Avoid off-label oral administration of injectable Vitamin K during the shortage.
  • Vitamin K from Amphastar contains polysorbate 80 and propylene glycol.
  • Vitamin K from Hospira contains benzyl alcohol. The product labeling states there is no evidence to suggest toxicity of benzyl alcohol if used as recommended.