Rezdiffra Dosage

Recommended Dosage and Administration

The recommended dosage of REZDIFFRA is based on actual body weight. For patients weighing:

• <100 kg, the recommended dosage is 80 mg orally once daily.
• ≥100 kg, the recommended dosage is 100 mg orally once daily.

Administer REZDIFFRA with or without food [see Clinical Pharmacology (12.3)].

Dosage Modifications for CYP2C8 Inhibitors

Concomitant use of REZDIFFRA with strong CYP2C8 inhibitors (e.g., gemfibrozil) is not recommended [see Drug Interactions (7.1)].

If REZDIFFRA is used concomitantly with a moderate CYP2C8 inhibitor (e.g., clopidogrel) [see Drug Interactions (7.1)], reduce the dosage of REZDIFFRA:

• <100 kg, reduce the dosage of REZDIFFRA to 60 mg once daily.
• ≥100 kg, reduce the dosage of REZDIFFRA to 80 mg once daily.