Acrivastine / Pseudoephedrine Dosage

Usual Adult Dose for Allergic Rhinitis

1 capsule orally every 4 to 6 hours
Maximum dosing frequency: 4 times a day

Comments:

• Use when both antihistaminic activity and nasal decongestant activity are desired.
• Efficacy beyond 14 days of continuous treatment has not been studied.

Use(s): Relief of symptoms associated with seasonal allergic rhinitis such as sneezing, rhinorrhea, pruritus, lacrimation, and nasal congestion

Usual Adult Dose for Nasal Congestion

1 capsule orally every 4 to 6 hours
Maximum dosing frequency: 4 times a day

Comments:

• Use when both antihistaminic activity and nasal decongestant activity are desired.
• Efficacy beyond 14 days of continuous treatment has not been studied.

Use(s): Relief of symptoms associated with seasonal allergic rhinitis such as sneezing, rhinorrhea, pruritus, lacrimation, and nasal congestion

Usual Pediatric Dose for Allergic Rhinitis

12 years and older:
1 capsule orally every 4 to 6 hours
Maximum dosing frequency: 4 times a day

Comments:

• Use when both antihistaminic activity and nasal decongestant activity are desired.
• Efficacy beyond 14 days of continuous treatment has not been studied.

Use(s): Relief of symptoms associated with seasonal allergic rhinitis such as sneezing, rhinorrhea, pruritus, lacrimation, and nasal congestion

Usual Pediatric Dose for Nasal Congestion

12 years and older:
1 capsule orally every 4 to 6 hours
Maximum dosing frequency: 4 times a day

Comments:

• Use when both antihistaminic activity and nasal decongestant activity are desired.
• Efficacy beyond 14 days of continuous treatment has not been studied.

Use(s): Relief of symptoms associated with seasonal allergic rhinitis such as sneezing, rhinorrhea, pruritus, lacrimation, and nasal congestion

Renal Dose Adjustments

Not recommended.

• Both active ingredients are primarily renally excreted and therefore accumulate in patients with impaired renal function.
• Use is not recommended in renal impairment (creatinine clearance 48 mL/min or less).

Liver Dose Adjustments

Data not available

Precautions

CONTRAINDICATIONS:

• Hypersensitivity to any of the ingredients
• Hypersensitivity to other alkylamine antihistamines (e.g. triprolidine) or other sympathomimetic amines (e.g. phenylpropanolamine)
• Severe hypertension
• Severe coronary artery disease
• Concomitant MAO inhibitors and for 14 days after stopping an MAO inhibitor

Safety and efficacy have not been established in patients younger than 12 years.

Consult WARNINGS section for additional precautions.

Dialysis

No adjustment recommended.

• The total body load removed by dialysis is about 20%; 27% for acrivastine and 38% for pseudoephedrine.
• A supplemental dose after dialysis is not required.

Other Comments

Patient advice:

• Advise patients to take this drug only as prescribed and not to exceed the prescribed dose.
• This medication should only be used during pregnancy or lactation if the benefits outweigh the risks.
• Do not take this medication if the patient is on a MAO inhibitor or has stopped a MAO inhibitor less than 14 days prior as there is a risk of hypertensive crisis.
• Patients should assess their reaction to this medication before driving or operating machinery.
• Avoid use with alcohol or CNS depressants as this may cause additional reductions in alertness and impairment of CNS performance.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer