Melatonin Alternatives Compared
Melatonin | Trazodone | Ambien |
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Melatonin | Trazodone | Ambien (zolpidem) |
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Prescription and OTC
Supplemental melatonin is very effective at reducing symptoms of jet lag, particularly that brought about by eastward travel across five or more time zones. Melatonin may also be used to treat sleep... View more |
Prescription only
Trazodone is mostly used for its sleep-inducing effects (an off-label indication) rather than as an antidepressant. Only generic forms are available which makes it a lot cheaper than some other... View more |
Prescription only
Ambien induces sleep; however, Ambien CR, in particular, may impair physical and mental capabilities the next day. Ambien has also been associated with complex or dangerous sleep-related behaviors... View more |
Related suggestions Popular comparisons
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More about Melatonin | More about Trazodone | More about Ambien (zolpidem) | ||||||||||||||||
Ratings & Reviews | ||||||||||||||||||
Melatonin has an average rating of 5.8 out of 10 from a total of 237 ratings on Drugs.com. 45% of reviewers reported a positive effect, while 36% reported a negative effect. |
Trazodone has an average rating of 6.3 out of 10 from a total of 1402 ratings on Drugs.com. 53% of reviewers reported a positive effect, while 31% reported a negative effect. |
Ambien has an average rating of 7.0 out of 10 from a total of 557 ratings on Drugs.com. 61% of reviewers reported a positive effect, while 21% reported a negative effect. |
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Drug Class | ||||||||||||||||||
Side Effects | ||||||||||||||||||
See also: melatonin side effects in more detail. |
See also: trazodone side effects in more detail. |
See also: Ambien side effects in more detail. |
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Generic Availability | ||||||||||||||||||
N/A |
Lower cost generic |
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Pricing and Coupons * Prices are without insurance | ||||||||||||||||||
We could not find an exact match for this medicine. Try searching the Price Guide directly. |
View all trazodone prices |
View all Ambien prices |
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Dosage Form(s) Available | ||||||||||||||||||
N/A |
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Brand Names | ||||||||||||||||||
Bio-Melatonin, Melatonin Time Release, SGard, Sleep3 |
N/A |
Other zolpidem brands include: Ambien CR, Edluar, Zolpimist | ||||||||||||||||
Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | ||||||||||||||||||
N/A |
7.5 hours |
2.6 hours |
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CSA Schedule ** View glossary of terms | ||||||||||||||||||
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Some potential for abuse
Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3. |
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Pregnancy Category | ||||||||||||||||||
Category N
Not classified
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Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
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Drug Interactions | ||||||||||||||||||
A total of 315 drugs are known to interact with melatonin:
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A total of 647 drugs are known to interact with trazodone:
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A total of 466 drugs are known to interact with Ambien:
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Alcohol/Food/Lifestyle Interactions | ||||||||||||||||||
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Disease Interactions | ||||||||||||||||||
First Approval Date | ||||||||||||||||||
N/A |
December 24, 1981 |
December 16, 1992 |
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WADA Class View World Anti-Doping Agency classifications. | ||||||||||||||||||
N/A |
N/A |
N/A |
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More Information | ||||||||||||||||||
Patient resources | ||||||||||||||||||
Professional Resources | ||||||||||||||||||
Related Treatment Guide | ||||||||||||||||||
** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.